0xb4707f8f0x0000001130000096508930000102243330000105342030000106184630000107007530000107043930000107044030000107044230000107044330000107044530000107044630000107044730000107044830000107044930000107045130000107045330000107045530000107045730000107045830000107046030000107046230000107046430000107046530000107046730000121524030000121527930000121528030000121528130000121528230000121528330000121528430000121528630000121528730000121528830000121528930000121529030000121529230000121529430000121529630000121529800You've passed! Try again, learn by doing!-12676957290x07d3300c,0x40626200,0x2b978c462

Today's lesson will cover DNA Transcription.This is the process cells use to make copies of DNA, which are used to build proteins.It's best to see this process close up, so follow Dweeble into the Shrinkolator.Follow the portals down into the body, then the cell, then into the nucleus.When you get to the DNA, take a closer look, and you'll see how it is put together.

-1Getting StartedSpeak to the teacher to find out about today's lesson.101

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DNA is composed of two strands, wrapped around each other in spiral, or HELIXThe strands are connected by complementary BASE PAIRS.Notice how each red CYTOSINE is paired with a blue GUANINE, and green ADENINE is paired with purple THYMINERemember that: it is very important.Let's take this DNA apart so we can make a copy!

-1InnerspaceTime to get close and personal with the DNA molecules.102

Helicase is an essential enzyme in transcription.It moves down the DNA strand to "'unzip"' it.

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-1Unzipping the DNALet's break some bonds! As you lead the helicase down the DNA, the hydrogen bonds linking the two sides of the DNA will break, and the strands will separate.106

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-1Synthesizing Messenger RNATake a pair of high-energy pyrophosphates and give it to a free RNA nucleotide. It will move to its complementary DNA nucleotide, and the polymerase will join it to the chain with a bang!109

-1Translation: mRNA to ProteinYou've made messenger RNA, or mRNA.Go through a nuclear pore and bring the messenger RNA to an active ribosome, which will use it as a recipe to make a protein! 109

-1Remember the Complements!This ribosome will take patterned codons and match them to their opposites on the mRNA. But it's missing one! Find the codon that complements Uracil Adenine Guanine!108

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Congratulations, you've passed the class!You can keep your protein as a souvenir.

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-1Home AgainA brand-new protein! Pick it up, and return to the classroom through the glowing portal to get your grade.1010You passed! And you know so much more about protein synthesis than you did before!13718046882UracilUracilUracilUracilUracilUracilUracilUracilUracil (Free RNA)30000107045300Adenine (Free RNA)30000107044700GuanineGuanine (Free RNA)30000107044800CytosineCytosineCytosineCytosineCytosineCytosineCytosineCytosineCytosine (Free RNA)300001070451003000010704430030000107044200300001070440000x90c48d09,0xd87454e6,0x00b1b104110x6bbb3bcd,0xd87454e6,0x00b1b1040030000107007500300001070445003000010704550030000106184600300001022433000x3144b430,0xd87454e6,0x00b1b10410Nuclear membraneNuclear membraneNuclear membraneNuclear membraneNuclear membraneNuclear membraneNuclear membraneNuclear membrane300001070439000x4b2cc563,0xd87454e6,0x00b1b104000x533cadba,0xd87454e6,0x00b1b104000x33d0c552,0xd87454e6,0x00b1b1040030000107044600Start CodonStart Codon30000107045700Stop CodonStopCodon30000107045800Nuclear Pore0x90c48d09,0xd87454e6,0x00b1b10411Nuclear poreNuclear poreNuclear poreNuclear poreNuclear poreNuclear poreNuclear poreNuclear pore30000107046000300001070465003000010704620030000107046400300001070467000x1bfeee76,0xd87454e6,0x00b1b10400Think happy thoughts.Don't you need a note from my mommy?30000096508900I'll be grading you on your performanceKeep going, you're doing....adequately.I'll be grading you on your performanceKeep going, you're doing....adequately.I'll be grading you on your performanceKeep going, you're doing....adequately.I'll be grading you on your performanceKeep going, you're doing....adequately.There may be hope for this one yet.I think you're getting it!There may be hope for this one yet.I think you're getting it!There may be hope for this one yet.I think you're getting it!There may be hope for this one yet.I think you're getting it!Mrs. Atoms300001053420000x07bfa144,0x40626200,0x2b978c46000x07bfa149,0x40626200,0x2b978c46000x90c48d09,0xd87454e6,0x00b1b104110xb4cfa915,0xd87454e6,0x00b1b10400I don't feel so well.I don't feel so well.I don't feel so well.I don't feel so well.I don't feel so well.I don't feel so well.I don't feel so well.I don't feel so well.300000965089000xe0083b25,0xd87454e6,0x00b1b104000xb4cfa915,0xd87454e6,0x00b1b104000x6f3624cf,0xd87454e6,0x00b1b104000x64a95186,0xd87454e6,0x00b1b104000x3d1e1222,0xd87454e6,0x00b1b10400I don't feel so well.I don't feel so well.I don't feel so well.I don't feel so well.I don't feel so well.I don't feel so well.I don't feel so well.I don't feel so well.30000096508900300001215280003000012152790030000107045100300001070448000x93512140,0xd87454e6,0x00b1b1040030000121528200DNA300001070457003000010704470030000107044900Thymine (separated)30000107044900Guanine (separated)30000107044800Adenine (separated)30000107044700RNA Polymerase: that factory that builds RNA3000012152810030000107044700300001070451003000010704480030000107044900Pyrophosphates0xc7c9cc8d,0xd87454e6,0x00b1b1042030000121528430000121528400We won't be using this half of the DNA to make RNA. We'll use the other strand.We won't be using this half of the DNA to make RNA. We'll use the other strand.We won't be using this half of the DNA to make RNA. We'll use the other strand.We won't be using this half of the DNA to make RNA. We'll use the other strand.We won't be using this half of the DNA to make RNA. We'll use the other strand.We won't be using this half of the DNA to make RNA. We'll use the other strand.We won't be using this half of the DNA to make RNA. We'll use the other strand.We won't be using this half of the DNA to make RNA. We'll use the other strand.30000121528300Messenger RNAMessenger RNA0xff562b48,0xd87454e6,0x00b1b104203000012152830xfa0722d4,0xd87454e6,0x00b1b104000x7ca661cf,0xd87454e6,0x00b1b10400Endoplasmic ReticulumWith Ribosomes!Endoplasmic ReticulumWith Ribosomes!Endoplasmic ReticulumWith Ribosomes!Endoplasmic ReticulumWith Ribosomes!Endoplasmic ReticulumWith Ribosomes!Endoplasmic ReticulumWith Ribosomes!Endoplasmic ReticulumWith Ribosomes!Endoplasmic ReticulumWith Ribosomes!30000121528700Active Ribosome300001215286003000012152400030000121529600Guanine Adenine GuanineGuanine Adenine GuanineGuanine Adenine GuanineGuanine Adenine GuanineGuanine Adenine GuanineGuanine Adenine GuanineGuanine Adenine GuanineGuanine Adenine Guanine0x48b8e425,0xd87454e6,0x00b1b10420300001215296Adenine Uracil UracilAdenine Uracil UracilAdenine Uracil UracilAdenine Uracil UracilAdenine Uracil UracilAdenine Uracil UracilAdenine Uracil UracilAdenine Uracil Uracil0x48b8e425,0xd87454e6,0x00b1b10420300001215290Adenine Uracil CytosineAdenine Uracil CytosineAdenine Uracil CytosineAdenine Uracil CytosineAdenine Uracil CytosineAdenine Uracil CytosineAdenine Uracil CytosineAdenine Uracil Cytosine 0xff562b48,0xd87454e6,0x00b1b10420300001215292Cytosine Adenine CytosineCytosine Adenine CytosineCytosine Adenine CytosineCytosine Adenine CytosineCytosine Adenine CytosineCytosine Adenine CytosineCytosine Adenine CytosineCytosine Adenine Cytosine 0x48b8e425,0xd87454e6,0x00b1b10420300001215289Adenine Cytosine GuanineAdenine Cytosine GuanineAdenine Cytosine GuanineAdenine Cytosine GuanineAdenine Cytosine GuanineAdenine Cytosine GuanineAdenine Cytosine GuanineAdenine Cytosine Guanine0x48b8e425,0xd87454e6,0x00b1b10420300001215288Guanine Uracil GuanineGuanine Uracil GuanineGuanine Uracil GuanineGuanine Uracil GuanineGuanine Uracil GuanineGuanine Uracil GuanineGuanine Uracil GuanineGuanine Uracil Guanine0x48b8e425,0xd87454e6,0x00b1b104203000012152940x90c48d09,0xd87454e6,0x00b1b104110x90c48d09,0xd87454e6,0x00b1b10411300001215298000xff562b48,0xd87454e6,0x00b1b104203000012152980x630fca5e,0xd87454e6,0x00b1b104000xd4d935e3,0xd87454e6,0x00b1b104000x7ca661cf,0xd87454e6,0x00b1b104000xda015f16,0xd87454e6,0x00b1b10400